Vitamins are organic substances that are essential for the proper growth and functioning of the body. People with liver or bile duct problems should not take turmeric supplements, as they can increase bile production. The supplement was discontinued and no further heart rhythm disturbances were noted in the six months that followed. Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat.

However, keep in mind that glucosamine is commonly derived from chitin — a compound found in shellfish. Generally, glucosamine and chondroitin are considered safe, though they may not be suitable for those with shellfish allergies, diabetes, or taking anticoagulant medication. Aspirin, Bayer Children's Aspirin, Ecotrin, and many others) is a NSAID used to treat fever, pain, and inflammation in the body that results from forms of arthritis, and soft tissue injuries.This may leave you wondering whether you should take glucosamine and chondroitin or if you’re better off without them. Cyclooxygenase-2 (COX-2) and matrix metalloproteinase (MMP) are two enzymes associated with joint tissue degradation. Some of these conditions include asthma, lung cancer, chronic obstructive pulmonary disease, and cystic fibrosis. This may lead to a variety of side effects, including shakiness, anxiety, blurred vision, delirium, and overall reduced cognitive function.

When taken in combination with these drugs, turmeric increases the body’s production of stomach acid.Often, these common gastrointestinal effects are mild and occur at a similar rate with placebo and turmeric in clinical trials. Thus, the authors concluded that chondroitin sulfate may be an effective pain remedy for those with knee osteoarthritis pain ( 10). Anemia: Since turmeric can impede iron absorption, turmeric supplements shouldn’t be taken with iron supplements. A 2017 double-blind, randomized study in 604 participants with knee osteoarthritis compared the effects of taking 800 mg/day of chondroitin sulfate, 200 mg/day of a popular NSAID known as celecoxib, and a placebo on osteoarthritis pain management ( 10). Turmeric is full of polyphenols or antioxidants that are known to protect the body from free radicals that can cause mutations in cellular DNA.

Boots has no control over the recipe or nutritional content of such products and information on this site may differ to that given on the product label. Involved in the immune response, COX-2 is upregulated in inflamed joint tissues, where the enzyme’s proinflammatory effects may detrimentally impact joint health, whereas MMP weakens connective tissues by degrading extracellular matrix proteins.

Capsule Shell (Beef Gelatin, Glycerol, Colour (Caramel)), Fish Oil, Glucosamine Sulphate Dipotassium Chloride ( Crustacean), Sunflower Seed Oil, Beeswax, Ascorbic Acid, Emulsifier (Sunflower Lecithin), Vitamin E Acetate, Manganese Sulphate, Antioxidant (Tocopherol), Vitamin D3 (Cholecalciferol). MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis. In fact, for general joint health and fitness support, it’s ideal to combine these ingredients, as part of a comprehensive multi-ingredient joint support stack.

Found all connective tissues and the extracellular matrix (ECM), proteoglycans are a class of heavily glycosylated proteins produced by chondrocyte cells using glucosamine as precursor material. If you’re interested in trying glucosamine and chondroitin, speak with a healthcare professional first to determine whether it’s right for you.

Taking turmeric in combination with blood thinners can strengthen their effects and increase the risk of internal bleeding. It can reduce blood clots, but makes it dangerous to take in combination withother blood-thinning medications. At Boots we understand how important your health and wellbeing is to be able to lead a fulfilling life. Just be mindful that high doses of turmeric may not be appropriate if a person has a severe medical condition and if the patient is pregnant or breastfeeding or taking certain medications. If you feel your joint health is beginning to deteriorate, taking Performance Lab® Flex can help get your joint tissues back on track.